Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 112 (8), 694-703

Transfusion-related Acute Lung Injury Risk Mitigation: An Update


Transfusion-related Acute Lung Injury Risk Mitigation: An Update

Z K Otrock et al. Vox Sang.


Transfusion-related acute lung injury (TRALI) is a life-threatening complication of transfusion. Greater understanding of the pathophysiology of this syndrome has much improved during the last two decades. Plasma-containing components from female donors with leucocyte antibodies were responsible for the majority of TRALI fatalities before mitigation strategies were implemented. Over the past 15 years, measures to mitigate risk for TRALI have been implemented worldwide and they continued to evolve with time. The AABB requires that all plasma containing components and whole blood for transfusion must be collected from men, women who have not been pregnant, or women who have tested negative for human leucocyte antigen antibodies. Although the incidence of TRALI has decreased following the institution of TRALI mitigation strategies, TRALI is still the most common cause of transfusion-associated death in the United States. In this review, we focus on TRALI risk mitigation strategies. We describe the measures taken by blood collection facilities to reduce the risk of TRALI in the United States, Canada and European countries. We also review the literature for the effectiveness of these measures.

Keywords: mitigation; review; risk; transfusion-related acute lung injury.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

LinkOut - more resources