[Studies on alkaloids from Melodinus moraei]

Yan Lu; Nai-Tao Shen; He-Yong Yu

doi:10.19540/j.cnki.cjcmm.20161222.006

[Studies on alkaloids from Melodinus moraei]

Zhongguo Zhong Yao Za Zhi. 2017 Jan;42(2):307-310. doi: 10.19540/j.cnki.cjcmm.20161222.006.

[Article in Chinese]

Authors

Yan Lu¹, Nai-Tao Shen¹, He-Yong Yu¹

Affiliation

¹ The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu 322000, China.

PMID: 28948736
DOI: 10.19540/j.cnki.cjcmm.20161222.006

Abstract

To study the alkaloids from Melodinus moraei,seven compounds were separated and purified by column chromatography over silica gel, reverse phase silica gel and preparative HPLC. Their chemical structures were elucidated by MS and spectral data (1H-NMR, 13C-NMR) as scandine(1),tabersonine(2),melodinine N(3),melodinine P(4), melodinine T(5),19-epimeloscandonine(6),16-hydroxy-19S-vindolinine(7). Compounds 1-7 were isolated from M. moraei for the first time．The bioassays showed all tested samples displayed antitumor activity against the cell lines such as A549,PC-3,HGC-27 and HL-60.

Keywords: Melodinus; Melodinus moraei; alkaloids; antitumor activity.

MeSH terms

Alkaloids / chemistry*
Apocynaceae / chemistry*
Cell Line, Tumor
Drugs, Chinese Herbal / chemistry*
Humans
Molecular Structure
Phytochemicals / chemistry
Proton Magnetic Resonance Spectroscopy

Substances

Alkaloids
Drugs, Chinese Herbal
Phytochemicals