Psychiatry has increasingly devoted its attention to the role of religion and spirituality in mental health and illness. All religions offer explanations for meaning and purpose of life, involving rationales for the reality of human suffering and traumas related to natural disasters, war, civil violence, torture, etc. In many countries different religious organizations have funded and operated mental health services as well as supported better understanding, empathy and compassion among cultures. A rapprochement between psychiatry and religion has been predicated on their overlapping goals to promote individual and community resilience, growth, and well-being. Due to progress in post-secular dialogue, psychiatry, religion and spiritual disciplines have the historical opportunity to shape the future of individual, public and global mental health as well as building compassionate society and empathic civilization.