Combining computer modelling and cardiac imaging to understand right ventricular pump function

Cardiovasc Res. 2017 Oct 1;113(12):1486-1498. doi: 10.1093/cvr/cvx154.


Right ventricular (RV) dysfunction is a strong predictor of outcome in heart failure and is a key determinant of exercise capacity. Despite these crucial findings, the RV remains understudied in the clinical, experimental, and computer modelling literature. This review outlines how recent advances in using computer modelling and cardiac imaging synergistically help to understand RV function in health and disease. We begin by highlighting the complexity of interactions that make modelling the RV both challenging and necessary, and then summarize the multiscale modelling approaches used to date to simulate RV pump function in the context of these interactions. We go on to demonstrate how these modelling approaches in combination with cardiac imaging have improved understanding of RV pump function in pulmonary arterial hypertension, arrhythmogenic right ventricular cardiomyopathy, dyssynchronous heart failure and cardiac resynchronization therapy, hypoplastic left heart syndrome, and repaired tetralogy of Fallot. We conclude with a perspective on key issues to be addressed by computational models of the RV in the near future.

Keywords: Arrhythmogenic right ventricular cardiomyopathy; Cardiac resynchronization therapy; CircAdapt; Congenital heart disease; Pulmonary arterial hypertension.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrhythmogenic Right Ventricular Dysplasia / complications
  • Arrhythmogenic Right Ventricular Dysplasia / diagnostic imaging
  • Arrhythmogenic Right Ventricular Dysplasia / physiopathology
  • Cardiac Imaging Techniques*
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / diagnostic imaging
  • Heart Defects, Congenital / physiopathology
  • Heart Failure / diagnostic imaging
  • Heart Failure / etiology
  • Heart Failure / physiopathology
  • Humans
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / diagnostic imaging
  • Hypertension, Pulmonary / physiopathology
  • Hypertrophy, Right Ventricular / diagnostic imaging*
  • Hypertrophy, Right Ventricular / etiology
  • Hypertrophy, Right Ventricular / physiopathology
  • Models, Cardiovascular
  • Myocardial Contraction*
  • Patient-Specific Modeling*
  • Predictive Value of Tests
  • Ventricular Dysfunction, Right / diagnostic imaging*
  • Ventricular Dysfunction, Right / etiology
  • Ventricular Dysfunction, Right / physiopathology
  • Ventricular Function, Right*