Oral manifestations of inflammatory bowel disease

J Biol Regul Homeost Agents. Jul-Sep 2017;31(3):817-821.


Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, have important extraintestinal manifestations, notably in the oral cavity. These oral manifestations can constitute important clinical clues in the diagnosis and management of IBD, and include changes at the immune and bacterial levels. Aphthous ulcers, pyostomatitis vegetans, cobblestoning and gingivitis are important oral findings frequently observed in IBD patients. Their presentations vary considerably and might be well diagnosed and distinguished from other oral lesions. Infections, drug side effects, deficiencies in some nutrients and many other diseases involved with oral manifestations should also be taken into account. This article discusses the most recent findings on the oral manifestations of IBD with a focus on bacterial modulations and immune changes. It also includes an overview on options for management of the oral lesions of IBD.

MeSH terms

  • Animals
  • Gingivitis* / immunology
  • Gingivitis* / microbiology
  • Gingivitis* / pathology
  • Gingivitis* / therapy
  • Humans
  • Inflammatory Bowel Diseases* / immunology
  • Inflammatory Bowel Diseases* / microbiology
  • Inflammatory Bowel Diseases* / pathology
  • Inflammatory Bowel Diseases* / therapy
  • Mouth* / immunology
  • Mouth* / microbiology
  • Mouth* / pathology
  • Stomatitis, Aphthous* / immunology
  • Stomatitis, Aphthous* / microbiology
  • Stomatitis, Aphthous* / pathology
  • Stomatitis, Aphthous* / therapy