GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias

Psychopharmacology (Berl). 1988;94(3):298-301. doi: 10.1007/BF00174678.

Abstract

Tetrahydroisoxazolopyridinol (THIP), a GABA receptor agonist, gamma-acetylenic-GABA(GAG) and gamma-vinyl-GABA(GVG), two GABA transaminase inhibitors were given in single parenteral doses to three Cebus apella monkeys with persistent dyskinetic movements induced by earlier long-term administration of haloperidol. High doses of THIP temporarily abolished dyskinesias but also caused bradykinesia, ataxia, dystonia and myoclonic jerks. GAG and GVG reduced dyskinesias to a lesser extent and with fewer side effects. Whether the observed antidyskinetic effect is secondary to the concomitant general toxic effects or if these drugs have a specific antidyskinetic action remains an open question.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminobutyrate Transaminase / antagonists & inhibitors
  • Alkynes
  • Aminocaproates / therapeutic use
  • Animals
  • Antipsychotic Agents / adverse effects*
  • Cebus
  • Dyskinesia, Drug-Induced / drug therapy*
  • Female
  • Isoxazoles / therapeutic use
  • Male
  • Vigabatrin
  • gamma-Aminobutyric Acid / physiology*

Substances

  • Alkynes
  • Aminocaproates
  • Antipsychotic Agents
  • Isoxazoles
  • gamma-Aminobutyric Acid
  • 4-amino-5-hexynoic acid
  • 4-Aminobutyrate Transaminase
  • Vigabatrin
  • gaboxadol