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. 2017 May 11;4:226-233.
doi: 10.1016/j.toxrep.2017.05.001. eCollection 2017.

Amelioration of the Cyclophosphamide Induced Genotoxic Damage in Mice by the Ethanolic Extract of Equisetum arvense

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Free PMC article

Amelioration of the Cyclophosphamide Induced Genotoxic Damage in Mice by the Ethanolic Extract of Equisetum arvense

Jasbir Kour et al. Toxicol Rep. .
Free PMC article

Abstract

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, simultaneous and post treatments and against its cytotoxicity as well. Because of its ability to prevent chromosomal damage, E. arvense is likely to open an interesting field concerning its possible use in clinical applications, most importantly in cancer as a chemopreventive agent or even as a coadjuvant to chemotherapy to reduce the side effects associated with it.

Keywords: Antimutagenicity; Chromosomal aberration assay; Equisetum arvense; GC–MS analysis; Mitotic index.

Figures

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Fig. 1
Fig. 1
GC–MS chromatogram of Ethanolic extract of Equisetum arvense.
Fig. 2
Fig. 2
Percentage reduction in chromosomal aberrations by different treatments with ethanol extract of Equisetum arvense.
Fig. 3
Fig. 3
% Mitotic Index of the bone marrow cells in different treatment groups.

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