Statement of problem: The casein phospho peptide-amorphous calcium phosphate with or without fluoride (CPP-ACPF and CPP-ACP respectively) are of considerably new materials which are highly recommended for prevention of dental caries. However, there is a shortage in literature on how they affect the ion concentration of saliva or dental plaque.
Objectives: The aim of this study was to evaluate the concentration of calcium, phosphate and fluoride in the plaque and saliva of children with Early Childhood Caries (ECC) after applying the CPP-ACP paste in comparison with the use of CPP-ACPF paste.
Materials and methods: One ml of un-stimulated saliva of 25 preschool children was collected and then 1 mg of the plaque sample was collected from the buccal surfaces of the two first primary molars on the upper jaw. CPP-ACP as well as CPP-ACPF pastes were applied on the tooth surfaces in two separate steps. In steps, plaque and saliva sampling was performed after 60 minutes. The amount of calcium ions was measured by Atomic Absorption Device and the amount of phosphate and fluoride ions was measured by Ion Chromatography instrument. Data were analyzed using Repeated Measurements ANOVA at a p < 0.05 level of significance.
Results: Application of both CPP-ACPF and CPP-ACP significantly increased the concentration of calcium, phosphate, and fluoride in both saliva and dental plaque. Moreover, significantly higher salivary fluoride concentration was seen after application of CPP-ACPF compared to CPP-ACP. No other significant difference was observed between these two materials.
Conclusions: CPP-ACPF can be more useful than CPP-ACP in protecting the primary teeth against caries process, especially when there is poor hygiene.
Keywords: Casein Phospho Peptide-Amorphous Calcium Phos-phate Fluoride; Saliva; Dental Plaque.
Conflict of interest statement
Conflict of interests: None declared.
Concentration of Calcium, Phosphate and Fluoride Ions in Microbial Plaque and Saliva After Using CPP-ACP Paste in 6-9 Year-Old ChildrenP Hr et al. J Dent Biomater 3 (2), 214-219. PMID 28959745.In this study, the use of the CPP-ACP paste significantly increased the fluoride levels of the plaque and the calcium and phosphate levels of both saliva and plaque. Henc …
Remineralizing Potential of Various Agents on Dental ErosionR Somani et al. J Oral Biol Craniofac Res 4 (2), 104-8. PMID 25737926.Casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF, Tooth Mousse Plus) can be recommended to be used in preventing erosive tooth wear from acidic b …
An in vitro Comparison of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste, Casein Phosphopeptide-Amorphous Calcium Phosphate Paste With Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate Varnish on the Inhibition of Demineralization and Promotion of Remineralization of EnamelPJ Thakkar et al. J Indian Soc Pedod Prev Dent 35 (4), 312-318. PMID 28914243.This study shows that CPP-ACPF varnish is effective in preventing demineralization as well as promoting remineralization of enamel. Thus, it can be used as an effective p …
Anticariogenicity of Casein Phosphopeptide-Amorphous Calcium Phosphate: A Review of the LiteratureC Llena et al. J Contemp Dent Pract 10 (3), 1-9. PMID 19430620. - ReviewRemineralization of white spot lesions has been achieved clinically by applying pastes based on these compounds, and a similar effect to self-applied fluorides has been o …
Review of Casein Phosphopeptides-Amorphous Calcium PhosphateSD Reema et al. Chin J Dent Res 17 (1), 7-14. PMID 25028684. - ReviewCasein phosphopeptides-amorphous calcium phosphate (CPP-ACP) is a bioactive agent with a base of milk products, which has been formulated from two parts: casein phosphope …
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