Integrative structure modeling with the Integrative Modeling Platform

Protein Sci. 2018 Jan;27(1):245-258. doi: 10.1002/pro.3311. Epub 2017 Oct 10.


Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (, and demonstrate its use.

Keywords: computational optimization; hybrid modeling; integrative modeling; structural biology.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Computational Biology*
  • Computer Simulation*
  • Models, Molecular*
  • Software*