A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion

Brain Res. 1988 Mar 22;444(2):346-50. doi: 10.1016/0006-8993(88)90944-4.


Somatostatin activates an inwardly rectifying potassium conductance in AtT-20 clonal corticotrophs, a cell line derived from the mouse pituitary gland. The action of somatostatin is blocked by pertussis toxin indicating that a GTP-binding protein couples the somatostatin receptor to the potassium channel. The potassium conductance is depressed by cesium. Cesium also attenuates the suppression of adrenocorticotropin hormone secretion by somatostatin suggesting that the increase in potassium conductance plays a role in this action of somatostatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / metabolism*
  • Animals
  • Cell Line
  • Cesium / pharmacology
  • Electric Conductivity
  • Membrane Potentials
  • Pertussis Toxin
  • Potassium / pharmacology*
  • Somatostatin / pharmacology*
  • Time Factors
  • Virulence Factors, Bordetella / pharmacology


  • Virulence Factors, Bordetella
  • Cesium
  • Somatostatin
  • Adrenocorticotropic Hormone
  • Pertussis Toxin
  • Potassium