Spinal Circuits for Touch, Pain, and Itch

Annu Rev Physiol. 2018 Feb 10;80:189-217. doi: 10.1146/annurev-physiol-022516-034303. Epub 2017 Sep 27.

Abstract

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somatosensory modalities of touch, pain, and itch. Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuron cell types. These include excitatory populations that transmit information about both innocuous and painful touch and inhibitory populations that serve as a gate to prevent innocuous stimuli from activating the nociceptive and pruritic transmission pathways. By dissecting the cellular composition of dorsal-horn networks, studies are beginning to elucidate the intricate computational logic of somatosensory transformation in health and disease.

Keywords: dorsal horn; gate control; interneuron; mechanosensation; nociception; somatosensory system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neural Pathways / physiology
  • Neural Pathways / physiopathology
  • Neurons / physiology
  • Pain / physiopathology*
  • Pruritus / physiopathology*
  • Spinal Cord / physiology*
  • Spinal Cord / physiopathology
  • Touch / physiology*