[Differential diagnosis of malignant hyperthermia, febrile catatonia and neuroleptic malignant syndrome. A case comparison]

Fortschr Neurol Psychiatr. 1988 Mar;56(3):97-101. doi: 10.1055/s-2007-1001774.
[Article in German]


Malignant Hyperthermia (MH), Lethal Catatonia (LC), and Neuroleptic Malignant Syndrome (NMS) are known as rare potential lethal diseases. MH and NMS--both being drug-induced--have in common some main symptoms. LC and NMS, on the other hand, are hardly distinguishable by clinical means. After presentation of the case reports the differential diagnosis of the syndromes is discussed. While there is strong evidence for the MH to be drug-induced, the NMS cannot be explained sufficiently in this way. Clinically both can be differentiated. Lethal catatonia is a syndrome rather than a specific disease. Differential diagnosis for NMS is possible by the neuroleptic withdraw-trial.

Publication types

  • Case Reports
  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Anesthesia, General
  • Antipsychotic Agents / adverse effects*
  • Catatonia / chemically induced*
  • Catatonia / diagnosis
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Malignant Hyperthermia / diagnosis*
  • Neuroleptic Malignant Syndrome / diagnosis*


  • Antipsychotic Agents