DNA polymorphism and the study of disease associations

Hum Genet. 1988 Apr;78(4):299-312. doi: 10.1007/BF00291724.

Abstract

Recombinant DNA approaches to disease analysis may be as applicable to studies of disease association as they are to the analysis and diagnosis of single-gene defects. Population and/or family association analyses, using restriction fragment length polymorphisms around candidate genes as markers, have been employed to study conditions such as atherosclerosis and disease with an HLA-association. Progress made to date in disease-association studies using recombinant DNA methodology is reviewed, the rationale behind such studies is examined and associated problems and pitfalls discussed.

Publication types

  • Review

MeSH terms

  • Alleles
  • Arteriosclerosis / genetics
  • DNA / analysis*
  • DNA, Recombinant
  • Disease Susceptibility / diagnosis
  • Ethics, Medical
  • Gene Frequency
  • Genetic Diseases, Inborn / genetics*
  • Genetic Linkage
  • Genetic Markers
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics
  • Humans
  • Models, Genetic
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*

Substances

  • DNA, Recombinant
  • Genetic Markers
  • HLA Antigens
  • DNA