New tools for understanding coping and resilience

Neurosci Lett. 2019 Feb 6;693:54-57. doi: 10.1016/j.neulet.2017.09.049. Epub 2017 Sep 27.


In humans, many of the factors determining vulnerability and resilience to the impact of an adverse event revolve around coping factors. This mini-review focuses on the neural mechanisms by which coping reduces the impact of adverse events, as studied in an animal model, and discusses some of the challenges of linking neural circuit activity with stressor outcome. We highlight several approaches for probing circuit function with cell-type and pathway-specificity that overcome some of the limitations of traditional neuroscience techniques and will likely yield a more detailed and comprehensive understanding of how the brain regulates stress-responsive structures when coping behaviors are engaged.

Keywords: Anxiety; Medial Prefrontal Cortex; Resilience; Serotonin; Stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Psychological / physiology*
  • Animals
  • Brain / physiopathology
  • Cognitive Neuroscience / methods
  • Humans
  • Models, Animal
  • Neural Pathways
  • Prefrontal Cortex / physiology
  • Resilience, Psychological*
  • Stress, Psychological