Safety of Contrast Material Use During Pregnancy and Lactation

Magn Reson Imaging Clin N Am. 2017 Nov;25(4):787-797. doi: 10.1016/j.mric.2017.06.010. Epub 2017 Sep 8.


The use of contrast media to image patients who are pregnant has increased during the past decades worldwide. Their use in pregnancy and in patients who are lactating remains a challenging issue for radiologists and other physicians. This article addresses the different types of contrast media that may be used in such patients according to the imaging modality (iodinated contrast media, barium, gadolinium-based, and ultrasound contrast agents), focusing on their adverse effects, potential teratogenic effects, strategies to minimize risks, and current clinical recommendation.

Keywords: Barium sulfate; Contrast media; Contrast-enhanced ultrasound; Gadolinium-based contrast media; Iodinate-based contrast media; Lactation; Pregnancy.

Publication types

  • Review

MeSH terms

  • Breast / drug effects
  • Contrast Media / adverse effects*
  • Diagnostic Imaging / methods*
  • Female
  • Gadolinium / adverse effects*
  • Humans
  • Lactation / drug effects*
  • Pregnancy
  • Pregnancy Complications / chemically induced*


  • Contrast Media
  • Gadolinium