Efficacy and Safety of Subcutaneous and Sublingual Immunotherapy for Allergic Rhinoconjunctivitis and Asthma

Otolaryngol Clin North Am. 2017 Dec;50(6):1111-1119. doi: 10.1016/j.otc.2017.08.011. Epub 2017 Sep 28.


Allergic rhinitis is often associated with asthma and has significant impacts on health care costs and productivity in the United States. Although allergen avoidance and pharmacotherapy are effective, allergen-specific immunotherapy is the only treatment that may lead to improved allergy symptoms even after treatment is discontinued. Subcutaneous immunotherapy has been the mainstay of allergen-specific immunotherapy in the United States for decades, but sublingual immunotherapy has recently become available. This review discusses the use of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of allergic rhinitis and asthma and reviews the current evidence regarding the safety and efficacy of both formulations.

Keywords: Allergen-specific immunotherapy; Allergic rhinitis; Subcutaneous immunotherapy; Sublingual immunotherapy.

Publication types

  • Review

MeSH terms

  • Administration, Cutaneous
  • Allergens / administration & dosage*
  • Asthma / therapy*
  • Desensitization, Immunologic / methods*
  • Humans
  • Randomized Controlled Trials as Topic
  • Rhinitis, Allergic / therapy*
  • Safety
  • Sublingual Immunotherapy*


  • Allergens