Evidence-Based Precision Oncology With the Cancer Targetome

Trends Pharmacol Sci. 2017 Dec;38(12):1085-1099. doi: 10.1016/j.tips.2017.08.006. Epub 2017 Sep 27.

Abstract

A core tenet of precision oncology is the rational choice of drugs to interact with patient-specific biological targets of interest, but it is currently difficult for researchers to obtain consistent and well-supported target information for pharmaceutical drugs. We review current drug-target interaction resources and critically assess how supporting evidence is handled. We introduce the concept of a unified Cancer Targetome to aggregate drug-target interactions in an evidence-based framework. We discuss current unmet needs and the implications for evidence-based clinical omics. The focus of this review is precision oncology but the discussion is highly relevant to targeted therapies in any area.

Keywords: Cancer Targetome; data curation; evidence-based medicine; molecular targeted therapy; precision medicine.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Evidence-Based Medicine
  • Humans
  • Medical Oncology / methods
  • Molecular Targeted Therapy / methods*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Precision Medicine / methods