Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice

Plant Foods Hum Nutr. 2017 Dec;72(4):445-447. doi: 10.1007/s11130-017-0633-2.

Abstract

The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (p < 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.

Keywords: Anticancer peptides; Bioactive peptides; Colon carcinogenesis; Common bean.

MeSH terms

  • Animals
  • Azoxymethane / toxicity
  • Colitis / chemically induced
  • Colitis / complications*
  • Colitis / prevention & control
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / drug therapy*
  • Dextran Sulfate / toxicity
  • Dietary Proteins / pharmacology*
  • Mice, Inbred BALB C
  • Phaseolus / chemistry*
  • Plant Extracts / chemistry

Substances

  • Dietary Proteins
  • Plant Extracts
  • Dextran Sulfate
  • Azoxymethane