Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

J Physiol Sci. 2018 Jan;68(1):19-31. doi: 10.1007/s12576-017-0571-7. Epub 2017 Sep 30.


A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Deeper knowledge of zinc's properties may help in treating metabolic syndrome, thus protecting against stroke and angina pectoris, and ultimately against death.

Keywords: Glucose metabolism; Inflammation; Lipid metabolism; Oxidative stress; Zinc.

Publication types

  • Review

MeSH terms

  • Animals
  • Glucose / metabolism*
  • Humans
  • Inflammation / metabolism*
  • Lipid Metabolism / physiology*
  • Lipids / physiology*
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism
  • Zinc / metabolism*


  • Lipids
  • Reactive Oxygen Species
  • Glucose
  • Zinc