Mild stimulation for in vitro fertilization

Fertil Steril. 2017 Oct;108(4):558-567. doi: 10.1016/j.fertnstert.2017.08.022.


It has been proven that the use of high gonadotropin dose does not necessarily improve the final outcome of IVF. Mild ovarian stimulation is based on the principle of optimal utilization of competent oocytes/embryos and endometrial receptivity. There is growing evidence that the pregnancy or live birth rates with mild-stimulation protocols are comparable to those with conventional IVF; the cumulative pregnancy outcome has been shown to be no different, despite having fewer numbers of oocytes or embryos available with milder ovarian stimulation. Although equally effective, mild-stimulation IVF is associated with a greater safety profile, in terms of the incidence of ovarian hyperstimulation syndrome and venous thromboembolism. It is also found to be better tolerated by patients and less expensive. Emerging research evidence may lead to widespread acceptance of mild IVF, by both patients and IVF providers, and make IVF more accessible to women and couples worldwide.

Keywords: Conventional stimulation; in vitro fertilization; mild stimulation; minimal stimulation.

Publication types

  • Review

MeSH terms

  • Birth Weight
  • Female
  • Fertilization in Vitro / adverse effects
  • Fertilization in Vitro / methods*
  • Humans
  • Infant, Newborn
  • Ovarian Hyperstimulation Syndrome / etiology
  • Ovarian Hyperstimulation Syndrome / prevention & control*
  • Ovulation Induction / adverse effects
  • Ovulation Induction / methods*
  • Pregnancy
  • Pregnancy Rate