Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies

Lancet. 1988 Apr 30;1(8592):969-71. doi: 10.1016/s0140-6736(88)91782-5.


Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes--hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Leukemia, Hairy Cell / metabolism
  • Leukemia, Hairy Cell / pathology*
  • Leukemia, Lymphoid / metabolism
  • Leukemia, Lymphoid / pathology*
  • Receptors, Cell Surface / metabolism
  • Receptors, Tumor Necrosis Factor
  • Thymidine / metabolism
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / metabolism
  • Tumor Necrosis Factor-alpha / pharmacology*


  • Receptors, Cell Surface
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Thymidine