Interactome of Obesity: Obesidome : Genetic Obesity, Stress Induced Obesity, Pathogenic Obesity Interaction

Adv Exp Med Biol. 2017;987:233-241. doi: 10.1007/978-3-319-57379-3_21.

Abstract

Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment (behavior, infectious agents, stress) interactions is a relative new field of great research interest. In this study, we have made an effort to create an interactome (henceforth referred to as "obesidome"), where extrinsic stressors response, intrinsic predisposition, immunity response to inflammation and autonomous nervous system implications are integrated. These pathways are presented in one interactome network for the first time. In our study, obesity-related genes/gene products were found to form a complex interactions network.

Keywords: Autonomic nervous system; Genetic obesity; Inflammation; Interactome; Obesidome; Pathogenic obesity; Stress induced obesity.

MeSH terms

  • Autonomic Nervous System / metabolism
  • Autonomic Nervous System / physiopathology
  • Gene Expression
  • Gene Regulatory Networks / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism
  • Inflammation / physiopathology
  • Obesity / genetics*
  • Obesity / metabolism
  • Protein Interaction Maps / genetics*
  • Stress, Physiological / genetics
  • Stress, Psychological / genetics