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. 2017 Oct 25;65(42):9237-9246.
doi: 10.1021/acs.jafc.7b03382. Epub 2017 Oct 17.

Gypenosides Reduced the Risk of Overweight and Insulin Resistance in C57BL/6J Mice Through Modulating Adipose Thermogenesis and Gut Microbiota

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Gypenosides Reduced the Risk of Overweight and Insulin Resistance in C57BL/6J Mice Through Modulating Adipose Thermogenesis and Gut Microbiota

Jie Liu et al. J Agric Food Chem. .

Abstract

This study investigated whether and how gypenosides from jiaogulan tea at 100 and 300 mg/kg/day levels could reduce the development of overweight and insulin resistance in C57 BL/6J mice fed a high-fat diet in 12 weeks. The 300 mg/kg/day gypenosides supplement significantly reduced final body weight, plasma total cholesterol, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index by 19.9%, 40%, and 36%, respectively, compared with the high-fat diet control group. Gypenosides also increased brown adipocyte tissue activity and white adipose tissue browning. The expression of genes involved in mitochondrial activity and fatty acid β-oxidation were also increased in both brown and white adipocyte tissues. In addition, gypenosides at 100 and 300 mg/kg/day levels decreased the ratio of Firmicutes to Bacteroidetes by 20% and 58.6%, respectively, and increased Akkermansia muciniphila abundance in the gut microbiota.

Keywords: brown adipocyte tissue; gypenosides; insulin resistance; microbiota; obesity; white adipocyte tissue.

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