WIPI β-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy

Autophagy. 2018;14(6):1082-1083. doi: 10.1080/15548627.2017.1382784. Epub 2018 Feb 3.

Abstract

The article discusses new findings on the role of the 4 human WIPI proteins at the onset of macroautophagy/autophagy. New insights revealing a circuit scaffold function of WIPI β-propellers that interconnect autophagy signaling control with appropriate autophagosome formation are summarized.

Keywords: WIPI1; WIPI2; WIPI3; WIPI4; autophagy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Autophagy*
  • Autophagy-Related Protein-1 Homolog / metabolism*
  • Humans
  • Models, Biological
  • Protein Structure, Secondary
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*

Substances

  • Autophagy-Related Protein-1 Homolog
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases

Grant support

Deutsche Forschungsgemeinschaft (DFG) FOR2625 (project 1) and SFB/TR (project B02).