Traumatic brain injury may not increase the risk of Alzheimer disease

Neurology. 2017 Oct 31;89(18):1923-1925. doi: 10.1212/WNL.0000000000004608. Epub 2017 Oct 4.


Traumatic brain injury (TBI) commonly occurs in civilian and military populations. Some epidemiologic studies previously have associated TBI with an increased risk of Alzheimer disease (AD). Recent clinicopathologic and biomarker studies have failed to confirm the relationship of TBI to the development of AD dementia or pathologic changes, and suggest that other neurodegenerative processes might be linked to TBI. Additional studies are required to determine the long-term consequences of TBI.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / etiology
  • Brain Injuries, Traumatic / complications
  • Brain Injuries, Traumatic / epidemiology*
  • Humans
  • Risk Factors