Emerging Properties and Functional Consequences of Noncoding Transcription

Genetics. 2017 Oct;207(2):357-367. doi: 10.1534/genetics.117.300095.


Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

Keywords: RNA Polymerase II transcription; chromatin; gene regulation; long noncoding RNA (lncRNA); nascent transcription; noncoding transcription; transcription cycle; transcriptional interference.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • Humans
  • RNA Polymerase II / metabolism
  • RNA Stability
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • Transcription, Genetic


  • Chromatin
  • RNA, Long Noncoding
  • RNA Polymerase II