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, 9 (8), 5107-5112

Anxiety and Depression in Patients With Gastroesophageal Reflux Disorder


Anxiety and Depression in Patients With Gastroesophageal Reflux Disorder

Seyed Alireza Haji Seyed Javadi et al. Electron Physician.


Background: Evidence shows an influence relationship between described symptoms of gastroesophageal reflux disorder (GERD) and emotional state.

Objective: To determine the relationship between anxiety and depression with GERD in patients referred to the endoscopy unit of Bouali-Sina Hospital in Qazvin.

Methods: This case-control study was conducted in the endoscopy unit of Bouali-Sina Hospital in Qazvin, Iran, from April 2014 through May 2015. Two hundred individuals (100 patients with GERD and 100 healthy individuals as a control group) were enrolled into the current study. All subjects completed the hospital anxiety and depression questionnaire. GERD was diagnosed based on the Los Angeles classification system. Demographic and socioeconomic characteristics in addition to clinical history of subjects were collected and analyzed using proper statistical methods (independent-samples t-test and AVOVA) and using SPSS version 22.

Results: Among the recruited patients, 50 subjects had erosive esophagitis (ERD) and 50 had non-erosive esophagitis (NERD). The anxiety score was significantly higher in the NERD group than the ERD and control groups (p=0.017; p<0.001). In addition, the anxiety score was significantly higher in the ERD group than the control group (p=0.014). The score of depression was higher in the NERD group than the ERD and the control groups. However, this difference was not statistically significant for the ERD group (p=0.63), but the difference was significant in comparison to the control group (p<0.001). There was no significant difference among the groups regarding age, gender or body mass index (BMI). The number of smokers was significantly higher in the ERD group than the NERD and control groups (p<0.001).

Conclusion: The current study showed that mental factors (anxiety and depression) play important roles in the development of GERD, especially NERD; therefore, it is recommended to consider these factors to select a suitable treatment plan.

Keywords: Anxiety; Depression; Gastro esophageal Reflux Disorder.

Conflict of interest statement

Conflict of Interest: There is no conflict of interest to be declared.


Figure 1
Figure 1
The Relationship Between Mental Disorders and the Study Groups

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    1. Roman S, Pandolfino JE, Kahrilas PJ. Gastroesophageal Reflux Disease. Yamada’s Textbook of Gastroenterology. 2016:906–28.
    1. Grossi L, Ciccaglione AF, Marzio L. Typical and atypical symptoms of gastro esophageal reflux disease: Does Helicobacter pylori infection matter? World journal of gastrointestinal pharmacology and therapeutics. 2015;6(4):238. doi: 10.4292/wjgpt.v6.i4.238. - DOI - PMC - PubMed
    1. Sharifi A, Dolatshahi S, Rezaeifar A, Ramim T. Sensitivity and specificity of endoscopy in diagnosis for Barrett’s esophagus. Tehran University Medical Journal. 2014;72(6):396–403.
    1. Kamolz T, Velanovich V. Psychological and emotional aspects of gastroesophageal reflux disease. Diseases of the Esophagus. 2002;15(3):199–203. doi: 10.1046/j.1442-2050.2002.00261.x. - DOI - PubMed
    1. Sanna L, Stuart AL, Berk M, Pasco JA, Girardi P, Williams LJ. Gastro oesophageal reflux disease (GORD)-related symptoms and its association with mood and anxiety disorders and psychological symptomology: a population-based study in women. BMC psychiatry. 2013;13(1):1. doi: 10.1186/1471-244X-13-194. - DOI - PMC - PubMed

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