Glutamate and dopamine modulate synaptic plasticity in horizontal cell dendrites of fish retina

Neurosci Lett. 1988 May 3;87(3):205-9. doi: 10.1016/0304-3940(88)90449-1.


Horizontal cell dendrites protruding into the cone pedicles in fish retina exhibit a light-dependent plasticity. In a light-adapted retina they form numerous spinules having membrane densities at their tips. These spinules disappear during dark adaptation. Experiments with light- or dark-adapted retinas which were incubated in glutamate or its agonists and antagonists, respectively, revealed that this putative cone transmitter is able to reduce the expression of spinules in a light-adapted retina. Dopamine, on the other hand, induces the formation of spinules in a dark-adapted retina and haloperidol reduces the expression in a light-adapted retina. These data suggest a control of spinules plasticity through two retinal neurotransmitter systems.

MeSH terms

  • Animals
  • Carps / physiology*
  • Cyprinidae / physiology*
  • Dendrites / drug effects
  • Dendrites / physiology*
  • Dendrites / ultrastructure
  • Dopamine / pharmacology*
  • Glutamates / pharmacology*
  • Glutamic Acid
  • Haloperidol / pharmacology
  • In Vitro Techniques
  • Kainic Acid / pharmacology
  • Lighting
  • Microscopy, Electron
  • Neuronal Plasticity / drug effects*
  • Retina / drug effects
  • Retina / physiology*
  • Retina / ultrastructure
  • Synapses / drug effects
  • Synapses / physiology
  • Synapses / ultrastructure


  • Glutamates
  • Glutamic Acid
  • Haloperidol
  • Kainic Acid
  • Dopamine