Idiopathic intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the dural venous sinus

J Neurosurg. 2018 Sep;129(3):723-731. doi: 10.3171/2017.4.JNS162871. Epub 2017 Oct 6.


OBJECTIVE Idiopathic intracranial hypertension (IIH) is commonly associated with venous sinus stenosis. In recent years, transvenous dural venous sinus stent (DVSS) insertion has emerged as a potential therapy for resistant cases. However, there remains considerable uncertainty over the safety and efficacy of this procedure, in particular the incidence of intraprocedural and delayed complications and in the longevity of sinus patency, pressure gradient obliteration, and therapeutic clinical outcome. The aim of this study was to determine clinical, radiological, and manometric outcomes at 3-4 months after DVSS in this treated IIH cohort. METHODS Clinical, radiographic, and manometric data before and 3-4 months after DVSS were reviewed in this single-center case series. All venographic and manometric procedures were performed under local anesthesia with the patient supine. RESULTS Forty-one patients underwent DVSS venography/manometry within 120 days. Sinus pressure reduction of between 11 and 15 mm Hg was achieved 3-4 months after DVSS compared with pre-stent baseline, regardless of whether the procedure was primary or secondary (after shunt surgery). Radiographic obliteration of anatomical stenosis correlating with reduction in pressure gradients was observed. The complication rate after DVSS was 4.9% and stent survival was 87.8% at 120 days. At least 20% of patients developed restenosis following DVSS and only 63.3% demonstrated an improvement or resolution of papilledema. CONCLUSIONS Reduced venous sinus pressures were observed at 120 days after the procedure. DVSS showed lower complication rates than shunts, but the clinical outcome data were less convincing. To definitively compare the outcomes between DVSS and shunts in IIH, a randomized prospective study is needed.

Keywords: DVSS = dural venous sinus stent; ICP = intracranial pressure; IIH = idiopathic intracranial hypertension; LP = lumboperitoneal; SSS = superior sagittal sinus; VP = ventriculoperitoneal; cerebrospinal fluid; dural venous sinus stenting; endovascular; idiopathic intracranial hypertension; interventional neurosurgery; intracranial pressure; venous sinus pressure.

MeSH terms

  • Acetazolamide / therapeutic use
  • Aged
  • Cohort Studies
  • Combined Modality Therapy
  • Constriction, Pathologic / surgery*
  • Continuous Positive Airway Pressure
  • Cranial Sinuses / surgery*
  • Female
  • Follow-Up Studies
  • Furosemide / therapeutic use
  • Humans
  • Intracranial Hypertension / surgery*
  • Male
  • Manometry*
  • Middle Aged
  • Phlebography*
  • Retrospective Studies
  • Stents*
  • Topiramate / therapeutic use
  • Treatment Outcome


  • Topiramate
  • Furosemide
  • Acetazolamide