Defective Human Immunodeficiency Virus (HIV) Particles Produced by Cloned Cells of HTLV-I-carrying MT-4 Cells Persistently Infected With HIV

Jpn J Cancer Res. 1988 Apr;79(4):418-23. doi: 10.1111/j.1349-7006.1988.tb01607.x.


Persistently HIV-infected cell lines were isolated from surviving and proliferating cells after infection of HTLV-I-carrying MT-4 cells with cell-free human immunodeficiency virus (HIV); HTLV-IIIB and LAV. The media of the cloned cell cultures did not cause HIV infection of MT-4, MOLT-4, TALL-1, or HL-60 cells. Most of the constituents of the virus in the media were env proteins and many defective doughnut-shaped particles released from the cells were identified by electron microscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Transformation, Viral
  • Clone Cells / microbiology
  • Clone Cells / ultrastructure
  • Defective Viruses / analysis
  • Defective Viruses / physiology*
  • Defective Viruses / ultrastructure
  • Deltaretrovirus / physiology*
  • Deltaretrovirus Infections / microbiology*
  • Deltaretrovirus Infections / pathology
  • HIV / analysis
  • HIV / physiology*
  • HIV / ultrastructure
  • Humans
  • Viral Envelope Proteins / isolation & purification
  • Virus Replication*


  • Viral Envelope Proteins