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. 2017 Oct 5;21(4):415-416.
doi: 10.1016/j.stem.2017.09.013.

E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion

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E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion

Jiyung Shin et al. Cell Stem Cell. .
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Abstract

In this issue of Cell Stem Cell, Tothova et al. (2017) demonstrate a promising way to model the complex genetics of clonal hematopoiesis and myeloid disorders using CRISPR-Cas9 genome editing in human hematopoietic stem and progenitor cells. Their approach opens the door to genotype-specific pharmacologic testing.

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