E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion

Jiyung Shin; Jacob E Corn

doi:10.1016/j.stem.2017.09.013

E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion

Cell Stem Cell. 2017 Oct 5;21(4):415-416. doi: 10.1016/j.stem.2017.09.013.

Authors

Jiyung Shin¹, Jacob E Corn²

Affiliations

¹ Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: jcorn@berkeley.edu.

PMID: 28985519
DOI: 10.1016/j.stem.2017.09.013

Abstract

In this issue of Cell Stem Cell, Tothova et al. (2017) demonstrate a promising way to model the complex genetics of clonal hematopoiesis and myeloid disorders using CRISPR-Cas9 genome editing in human hematopoietic stem and progenitor cells. Their approach opens the door to genotype-specific pharmacologic testing.

Publication types

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MeSH terms

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Editing*
Hematopoiesis
Hematopoietic Stem Cells
Humans
Neoplasms / genetics*