E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion

Cell Stem Cell. 2017 Oct 5;21(4):415-416. doi: 10.1016/j.stem.2017.09.013.


In this issue of Cell Stem Cell, Tothova et al. (2017) demonstrate a promising way to model the complex genetics of clonal hematopoiesis and myeloid disorders using CRISPR-Cas9 genome editing in human hematopoietic stem and progenitor cells. Their approach opens the door to genotype-specific pharmacologic testing.

Publication types

  • Comment

MeSH terms

  • CRISPR-Cas Systems
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gene Editing*
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Neoplasms / genetics*