Cocos nucifera water improves metabolic functions in offspring of high fat diet fed Wistar rats

J Basic Clin Physiol Pharmacol. 2018 Mar 28;29(2):185-194. doi: 10.1515/jbcpp-2017-0005.


Background: Maternal high fat diet has been implicated in the aetiology of metabolic diseases in their offspring. The hypolipidaemic actions of Cocos nucifera water improve metabolic indices of dams consuming a high fat diet during gestation. This study investigated the effects of C. nucifera water on metabolism of offspring of dams exposed to high fat diet during gestation.

Methods: Four groups of pregnant Wistar rat dams (n=6) were treated orally from Gestation Day (GD) 1 to GD 21 as follows: standard rodent feed+10 mL/kg distilled water (Control), standard rodent feed+10 mL/kg C. nucifera water, high fat feed+10 mL/kg distilled water (high fat diet), and high fat feed+10 mL/kg C. nucifera water (high fat diet+C. nucifera water). The feeds were given ad libitum and all dams received standard rodent feed after parturition. Fasting blood glucose was measured in offspring before being euthanized on Postnatal Day (PND) 120. Serum insulin, leptin, lipid profile and liver enzymes were measured.

Results: Serum total cholesterol (TC), insulin, alanine transaminase (ALT) and alkaline phosphatase levels were significantly increased (p<0.05) in high fat diet offspring compared with controls. Similar changes were not observed in high fat diet+C. nucifera water offspring.

Conclusions: Results suggest that the adverse effects of maternal high fat diet on offspring's metabolism can be ameliorated by C. nucifera water.

Keywords: Cocos nucifera water; foetal programming; maternal high fat diet; metabolism.

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Cocos / chemistry*
  • Diet, High-Fat / adverse effects*
  • Female
  • Insulin / metabolism
  • Leptin / metabolism
  • Lipid Metabolism / drug effects
  • Metabolism / drug effects*
  • Obesity / metabolism
  • Plant Extracts / pharmacology*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / metabolism
  • Rats
  • Rats, Wistar
  • Water / pharmacology*


  • Blood Glucose
  • Insulin
  • Leptin
  • Plant Extracts
  • Water