Safe, live Vibrio cholerae vaccines?

Vaccine. 1988 Apr;6(2):151-4. doi: 10.1016/s0264-410x(88)80019-7.


Mutants of Vibrio cholerae defective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. The tcp operon has been cloned and strains of V. cholerae have been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Administration, Oral
  • Cholera Vaccines / immunology
  • Cholera Vaccines / isolation & purification*
  • Cloning, Molecular
  • DNA Transposable Elements
  • Fimbriae, Bacterial / immunology*
  • Gene Expression Regulation
  • Mutation
  • Vaccines, Attenuated / immunology
  • Vaccines, Attenuated / isolation & purification
  • Vibrio cholerae / genetics*


  • Cholera Vaccines
  • DNA Transposable Elements
  • Vaccines, Attenuated