Silver-mediated oxidative C-H difluoromethylation of phenanthridines and 1,10-phenanthrolines

Sheng-Qing Zhu; Xiu-Hua Xu; Feng-Ling Qing

doi:10.1039/c7cc05411d

Silver-mediated oxidative C-H difluoromethylation of phenanthridines and 1,10-phenanthrolines

Chem Commun (Camb). 2017 Oct 17;53(83):11484-11487. doi: 10.1039/c7cc05411d.

Authors

Sheng-Qing Zhu¹, Xiu-Hua Xu, Feng-Ling Qing

Affiliation

¹ Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China. flq@mail.sioc.ac.cn.

PMID: 28990036
DOI: 10.1039/c7cc05411d

Abstract

A silver-mediated oxidative difluoromethylation of phenanthridines and 1,10-phenanthrolines with TMSCF₂H is disclosed. This C-H difluoromethylation of N-containing polycyclic aromatics constitutes an efficient method for the regioselective synthesis of difluoromethylated N-heterocycles.