Crystal structure of a DNA duplex containing four Ag(i) ions in consecutive dinuclear Ag(i)-mediated base pairs: 4-thiothymine-2Ag(i)-4-thiothymine

Jiro Kondo; Toru Sugawara; Hisao Saneyoshi; Akira Ono

doi:10.1039/c7cc06153f

Crystal structure of a DNA duplex containing four Ag(i) ions in consecutive dinuclear Ag(i)-mediated base pairs: 4-thiothymine-2Ag(i)-4-thiothymine

Chem Commun (Camb). 2017 Aug 22;53(86):11747-11750. doi: 10.1039/c7cc06153f.

Authors

Jiro Kondo¹, Toru Sugawara, Hisao Saneyoshi, Akira Ono

Affiliation

¹ Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan. j.kondo@sophia.ac.jp.

PMID: 28991300
DOI: 10.1039/c7cc06153f

Abstract

Herein, we determined a high-resolution crystal structure of a B-form DNA duplex containing consecutive dinuclear metal ion-mediated base pairs, namely, 4-thiothymine-2Ag(i)-4-thiothymine (S-2Ag(i)-S), and four Ag(i) ions form a rectangular network and the distances between the Ag(i) ions are 2.8-3.2 Å, which may indicate the existence of metallophilic attractions.