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Case Reports
. 2018 May;178(5):1196-1198.
doi: 10.1111/bjd.16045. Epub 2018 Feb 23.

Low-dose Naltrexone: A Novel Treatment for Hailey-Hailey Disease

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Case Reports

Low-dose Naltrexone: A Novel Treatment for Hailey-Hailey Disease

V Campbell et al. Br J Dermatol. .

Abstract

Hailey-Hailey disease (chronic benign familial pemphigus) is a rare inherited dermatosis typically characterized by erosions at intertriginous sites preceded by minor trauma or stress. We report a case of treatment-resistant Hailey-Hailey disease having failed topical and oral steroids, prophylactic aciclovir and doxycycline, and systemic therapies including dapsone, acitretin and ciclosporin. Low-dose naltrexone 4·5 mg once daily was commenced following an incidental benefit in this patient's similarly affected sister. The clinical and psychological response to date has been considerable.

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