Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes

Keisha Harrison; Stephanie Sisley

doi:10.1016/j.jsbmb.2017.10.005

Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes

J Steroid Biochem Mol Biol. 2018 Mar:177:125-128. doi: 10.1016/j.jsbmb.2017.10.005. Epub 2017 Oct 6.

Authors

Keisha Harrison¹, Stephanie Sisley²

Affiliations

¹ Department of Pediatrics, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030, USA. Electronic address: Keisha.Harrison@bcm.edu.
² Department of Pediatrics, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030, USA. Electronic address: Stephanie.sisley@bcm.edu.

PMID: 28993246
DOI: 10.1016/j.jsbmb.2017.10.005

Abstract

Vitamin D deficiency is linked to type 2 diabetes and we recently showed this may be through action of vitamin D in the paraventricular nuclei (PVN) in the hypothalamus of the brain. This review focuses on the known roles of the PVN in glucose control and how previously discovered actions of vitamin D in other tissues may translate to action in the PVN. Specifically, we focus on the role of insulin and inflammation in the hypothalamus and how these may be modified through vitamin D action.

Keywords: Brain; Glucose regulation; Hepatic glucose control; Hypothalamus; Inflammation; Insulin; Vitamin D.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Brain / metabolism*
Diabetes Mellitus, Type 2 / metabolism*
Glucose / metabolism
Humans
Vitamin D / metabolism*

Substances

Vitamin D
Glucose