Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes

J Steroid Biochem Mol Biol. 2018 Mar;177:125-128. doi: 10.1016/j.jsbmb.2017.10.005. Epub 2017 Oct 6.

Abstract

Vitamin D deficiency is linked to type 2 diabetes and we recently showed this may be through action of vitamin D in the paraventricular nuclei (PVN) in the hypothalamus of the brain. This review focuses on the known roles of the PVN in glucose control and how previously discovered actions of vitamin D in other tissues may translate to action in the PVN. Specifically, we focus on the role of insulin and inflammation in the hypothalamus and how these may be modified through vitamin D action.

Keywords: Brain; Glucose regulation; Hepatic glucose control; Hypothalamus; Inflammation; Insulin; Vitamin D.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Glucose / metabolism
  • Humans
  • Vitamin D / metabolism*

Substances

  • Vitamin D
  • Glucose