Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users

J Pharm Pharmacol. 1988 May;40(5):374-5. doi: 10.1111/j.2042-7158.1988.tb05272.x.

Abstract

The aim of this study was to characterize the elimination half-life of delta 1-tetrahydrocannabinol in blood plasma in chronic marijuana users. The subjects smoked four cigarettes during a two day period, each cigarette containing 15 mg deuterium-labelled delta 1-tetrahydrocannabinol. The plasma concentrations of deuterium-labelled tetrahydrocannabinol were measured for 13 days using gas chromatography-mass spectrometry equipped with selected ion monitoring. The elimination half-life for delta 1-tetrahydrocannabinol in blood plasma was calculated to be 4.1 +/- 1.1 days (range 2.9-5.0 days) from the two week plasma level curves. Albeit the present results are based upon a small sample, an elimination half-life of delta 1-tetrahydrocannabinol in blood plasma of about 4 days is more in line with apparent half-life excretion of delta 1-tetrahydrocannabinol metabolites in the urine of chronic marijuana smokers.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Dronabinol / blood
  • Dronabinol / pharmacokinetics*
  • Half-Life
  • Humans
  • Male
  • Marijuana Abuse / blood*

Substances

  • Dronabinol