Reflotron, a solid phase reagent technology capable of measuring a wide range of analytes on whole blood, plasma or serum samples has been evaluated with reference to urea, glucose, cholesterol, triacylglycerols, haemoglobin and gamma-glutamyltransferase analyses. The results show good concordance with conventional wet chemistry methods, with comparable imprecision. Performance is not affected by variations in haematocrit up to 0.55 or bilirubin concentrations at least up to 250 mumol/l.