Flavonoids, leucocyte migration and eicosanoids

J Pharm Pharmacol. 1988 Apr;40(4):293-5. doi: 10.1111/j.2042-7158.1988.tb05250.x.

Abstract

Quercetin reduced the concentration of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the pleural exudate induced in rats by 1% carrageenan given intrapleurally. Leucocyte migration in the exudate was also reduced by the flavonoid. Inhibition of eicosanoids and leucocytes in the exudate was dose-related. Quercetin also reduced LTB4 synthesis in cells stimulated with ionophore A23187, either ex-vivo or in-vitro. A similar, though less active, mode of action was found with quercitrin, while apigenin and luteolin reduced leucocyte accumulation and PGE2 formation, but not LTB4-formation.

MeSH terms

  • Animals
  • Cell Movement
  • Dinoprostone
  • Flavonoids / pharmacology*
  • Leukocytes / immunology*
  • Leukotriene B4 / biosynthesis*
  • Male
  • Pleural Effusion / immunology*
  • Pleural Effusion / metabolism
  • Prostaglandins E / biosynthesis*
  • Rats
  • Rats, Inbred Strains

Substances

  • Flavonoids
  • Prostaglandins E
  • Leukotriene B4
  • Dinoprostone