Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis

Lancet. 1988 Aug 20;2(8608):421-4. doi: 10.1016/s0140-6736(88)90413-8.


Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Factor VIII / metabolism
  • Female
  • Fibrin / metabolism*
  • Glomerulonephritis / immunology*
  • Glomerulonephritis / metabolism
  • Glomerulonephritis / pathology
  • Humans
  • Hypersensitivity, Delayed / metabolism
  • Immunity, Cellular
  • Macrophages / pathology
  • Male
  • Middle Aged
  • T-Lymphocytes / pathology
  • Thromboplastin / metabolism


  • Factor VIII
  • Fibrin
  • Thromboplastin