Cyclophosphamide and tamoxifen as adjuvant therapies in the management of breast cancer. CRC Adjuvant Breast Trial Working Party

Br J Cancer. 1988 Jun;57(6):604-7. doi: 10.1038/bjc.1988.137.


In 1980 the Cancer Research Campaign launched a multi-centre breast cancer trial; aimed at repeating the Scandinavian Chemotherapy Study Group's cyclophosphamide trial, and the NATO tamoxifen study; thereby further evaluating the role of these two adjuvant regimens in patients with early breast cancer. Two thousand two hundred and thirty women were randomized into this trial between 1980 and 1985 and preliminary analyses demonstrate a significant improvement in event-free survival for both regimens. Results from this study closely parallel the two trials it set out to repeat.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / therapy
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Cyclophosphamide / therapeutic use*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Menopause
  • Middle Aged
  • Random Allocation
  • Tamoxifen / therapeutic use*


  • Tamoxifen
  • Cyclophosphamide