The molecular genetics of embryonic pattern formation in Drosophila

Nature. 1988 Sep 1;335(6185):25-34. doi: 10.1038/335025a0.


Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactions between transcriptional regulators; the second occurs after cellularization and depends on communication between cells. These processes may be conserved in a wide range of invertebrates and vertebrates.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Cell Differentiation*
  • Drosophila / embryology
  • Drosophila / genetics*
  • Embryonic Induction*
  • Genes, Homeobox
  • Nervous System / embryology