Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia

J Cereb Blood Flow Metab. 1988 Oct;8(5):757-62. doi: 10.1038/jcbfm.1988.124.

Abstract

The effects of the glutamate N-methyl-D-aspartate receptor antagonist MK-801 in reducing ischaemic brain damage have been examined in anaesthetised cats, with drug treatment being initiated 2 h after the induction of cerebral ischaemia. Focal cerebral ischaemia was produced by permanent occlusion of one middle cerebral artery, and the animals were killed 6 h later. The amount of early irreversible ischaemic damage was assessed at 16 predetermined stereotactic planes. Treatment with MK-801 (5 mg/kg, i.v.) 2 h after middle cerebral artery occlusion reduced significantly the volume of ischaemic damage (from 1,625 +/- 384 mm3 of the cerebral hemisphere in vehicle-treated cats to 792 +/- 385 mm3 in MK-801-treated cats). The demonstration of reduced ischaemic brain damage with MK-801, when the agent is administered after the induction of ischaemia, extends the therapeutic potential of such agents in the treatment of focal cerebral ischaemia in humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / pharmacology*
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / antagonists & inhibitors
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / pathology
  • Cats
  • Dibenzocycloheptenes / administration & dosage
  • Dibenzocycloheptenes / pharmacology*
  • Disease Models, Animal
  • Dizocilpine Maleate
  • Excitatory Amino Acid Antagonists
  • Glutamic Acid
  • N-Methylaspartate

Substances

  • Anticonvulsants
  • Dibenzocycloheptenes
  • Excitatory Amino Acid Antagonists
  • Aspartic Acid
  • Glutamic Acid
  • N-Methylaspartate
  • Dizocilpine Maleate