Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus

Lancet. 1988 Oct 1;2(8614):764-6. doi: 10.1016/s0140-6736(88)92416-6.

Abstract

In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus amarus for 30 days. 22 of 37 (59%) treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. Some subjects have been followed for up to 9 months. In no case has the surface antigen returned. Clinical observation revealed few or no toxic effects. The encouraging results of this preliminary study recommend continued evaluation of this plant and the active principles isolated from it.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Carrier State / drug therapy*
  • Carrier State / etiology
  • Carrier State / immunology
  • Child
  • Child, Preschool
  • Chronic Disease
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Hepatitis B / complications
  • Hepatitis B / drug therapy*
  • Hepatitis B / immunology
  • Hepatitis B Antigens / analysis
  • Hepatitis B virus / immunology
  • Humans
  • Male
  • Plants, Medicinal*
  • Random Allocation

Substances

  • Hepatitis B Antigens