Tumor Suppression by p53: Bring in the Hippo!

Cancer Cell. 2017 Oct 9;32(4):397-399. doi: 10.1016/j.ccell.2017.09.010.


In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target. PTPN14 restrains YAP, curbing its potential oncogenic effects. The p53-PTPN14-YAP axis highlights the importance of signaling pathway coordination in cancer prevention.

Publication types

  • Comment

MeSH terms

  • Hippo Signaling Pathway
  • Humans
  • Oncogenes
  • Pancreatic Neoplasms*
  • Phosphoproteins / genetics
  • Protein Serine-Threonine Kinases
  • Protein Tyrosine Phosphatases, Non-Receptor / genetics
  • Signal Transduction
  • Tumor Suppressor Protein p53*


  • Phosphoproteins
  • Tumor Suppressor Protein p53
  • Protein Serine-Threonine Kinases
  • PTPN14 protein, human
  • Protein Tyrosine Phosphatases, Non-Receptor