Bidirectional terminators: an underestimated aspect of gene regulation

Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y. Epub 2017 Oct 10.


Recent experimental and computational work revealed that transcriptional terminators in Saccharomyces cerevisiae can terminate transcription coming from both directions. This mechanism helps budding yeast cope with the pervasive nature of transcription by limiting aberrant transcription from invading neighboring genes.

Keywords: Bidirectional terminators; Cryptic transcription; Hrp1; Pervasive transcription; Saccharomyces cerevisiae; Transcription.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Fungal*
  • Promoter Regions, Genetic
  • RNA Stability / genetics
  • RNA, Fungal / genetics
  • RNA, Messenger / genetics
  • Saccharomyces cerevisiae / genetics*
  • Transcription Termination, Genetic*
  • Transcription, Genetic*


  • RNA, Fungal
  • RNA, Messenger

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