Diffusion is fundamental to the random movement of solutes in solution throughout biological systems. Theoretical studies of diffusing solutes across cell membranes confined in a microscopic size of pores have been an interesting subject in life and medical sciences. When a solute is confined in a critical area of membrane pores, which shows a quite different behavior compared to the homogeneous-bulk fluid whose transport is isotropic in all directions. This property has novel features, which are of considerable physiological interest.
Keywords: Interfaces; Ion channels; Ionophores; Lateral pressure profile; Line and surface tensions; Liposomes; Mechanosensitive channels; Porins; Tortuosity; α-/ β-helixes.