The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats

Biol Trace Elem Res. 2018 Jul;184(1):165-172. doi: 10.1007/s12011-017-1182-0. Epub 2017 Oct 10.


In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200-250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b.w.) i.p. STZ-induced diabetes; group 3, 5 mg/kg (b.w.) B; group 4, 10 mg/kg (b.w.) B; group 5, diabetes + 5 mg/kg (b.w.) B; and group 6, diabetes + 10 mg/kg (b.w.) B. The experiment lasted 4 weeks. Increased serum MDA levels with diabetes were significantly reduced and although it is not statistically significant, serum TAC levels approached to values of control group; also, insignificant increases were observed in HDL cholesterol levels in experimental diabetic rats with treatment 5 and 10 mg/kg B. Furthermore, body weight, plasma insulin, and lipase activities increased insignificantly, blood glucose and serum LDL cholesterol decreased significantly, and total cholesterol levels decreased insignificantly in the diabetes + 10 mg/kg B group. There was no difference between the groups in terms of plasma PON1 activities and serum triglyceride levels. In conclusion, B may have beneficial effects on some biochemical parameters changes in experimental diabetes, and in order to determine the full effect of this element on the metabolism, further studies are required which use various dosages and compounds of B.

Keywords: Biochemical parameters; Body weight; Boron; Diabetes; Rat.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Aryldialkylphosphatase / metabolism
  • Blood Glucose / drug effects
  • Body Weight / drug effects
  • Boric Acids / pharmacology
  • Boron / therapeutic use*
  • Cholesterol / blood
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism*
  • Lipid Peroxidation / drug effects
  • Lipoproteins, HDL / blood
  • Male
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Wistar
  • Triglycerides / blood


  • Antioxidants
  • Blood Glucose
  • Boric Acids
  • Lipoproteins, HDL
  • Triglycerides
  • Cholesterol
  • Pon1 protein, rat
  • Aryldialkylphosphatase
  • Boron
  • boric acid