The definition of the Brugada syndrome

Eur Heart J. 2017 Oct 21;38(40):3029-3034. doi: 10.1093/eurheartj/ehx490.


Brugada syndrome (BS) is an inherited disease characterized by a coved-type ST-segment elevation in the right precordial leads and increased risk of sudden cardiac death (SCD), in the absence of structural abnormalities. The cornerstone of BS diagnosis and definition, is its characteristic ECG pattern that can be present spontaneously or unmasked by drugs. Brugada syndrome was first described 25 years ago; paradoxically, in an era of great technological development, a new syndrome was described with a technology developed almost a century before. Great scientific knowledge has been gathered since the description of the syndrome. The better understanding of its pathophysiology and genetic basis has led to several modifications in its definition. Despite these facts, the essential, the description of the specific ECG pattern has remained almost unchanged since the initial report. In this article, we present the definition of the BS, the rationale behind it and our thoughts about its future.

Keywords: Brugada syndrome; Definition; Sudden cardiac death.

Publication types

  • Review

MeSH terms

  • Brugada Syndrome / diagnosis*
  • Brugada Syndrome / genetics
  • Consensus
  • Death, Sudden, Cardiac / etiology
  • Electrocardiography
  • Forecasting
  • Humans
  • Ion Channels / genetics
  • Publications / statistics & numerical data
  • Publications / trends


  • Ion Channels